ent-Tadalafil |
| Catalog No.GC39288 |
ent-Tadalafil(ent-IC-351), 화합물(6S,12aS)은 화합물(6R,12aS)의 비활성 시스-거울상 이성질체입니다. 화합물(6R,12aS)은 IC50이 0.090μM인 강력한 PDE5 억제제인 반면, ent-Tadalafil은 최대 10μM 농도에서 비활성화됩니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 629652-72-8
Sample solution is provided at 25 µL, 10mM.
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ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM[1].
[1]. Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.J Med Chem. 2003 Oct 9;46(21):4533-42.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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