Alclofenac

Alclofenac is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, and anti-pyretic properties.^1,2,3 It inhibits contractions induced by serotonin (5-HT) in isolated guinea pig ileum by 28% when used at a concentration of 200 μg/ml.⁴ Alclofenac (480 mg/kg per day) decreases implant neutrophil and macrophage infiltration in a rat model of irritant-induced inflammation induced by implantation of heat-killed M. tuberculosis-impregnated polyurethane cubes.⁵

1.Delbeke, F.T., Landuyt, J., and Debackere, M.Disposition of human drug preparations in the horse. III. Orally administered alclofenacJ. Vet. Pharmacol. Ther.17(5)353-358(1994) 2.Staquet, M., Luyckx, A., and Van Cauwenberge, H.A double-blind comparison of alclofenac, pentazocine, and codeine with placebo control in pathologic painJ. Clin. Pharmacol. New Drugs11(6)450-455(1971) 3.Berry, H., Fernandes, L., Ford-Hutchinson, A.W., et al.Alclofenac and ?-penicillamine. Comparative trial in rheumatoid arthritisAnn. Rheum. Dis.37(1)93-97(1978) 4.Famaey, J.P., Fontaine, J., Seaman, I., et al.A possible role of prostaglandins in guinea-pig isolated ileum contractions to serotoninProstaglandins14(1)119-124(1977) 5.Woodland, J., Vernon-Roberts, B., Swettenham, K.V., et al.Comparison of the effects of alclofenac, flurbiprofen, and prednisolone on acute inflammatory response in the ratAnn. Rheum. Dis.36(2)160-165(1977)