Docetaxel-d9 (Synonyms: DTX-d9, Taxotel-d9) |
| Catalog No.GC47250 |
도세탁셀-d9(RP-56976-d9)는 도세탁셀로 표시된 중수소입니다. Docetaxel(RP-56976)은 IC50이 0.2μM인 미세소관 해중합 억제제입니다. 도세탁셀은 bcl-2 및 bcl-xL 유전자 발현의 효과를 약화시킵니다. Docetaxel은 G2/M에서 세포 주기를 정지시키고 세포 사멸을 유도합니다. 도세탁셀은 항암 활성이 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 940867-25-4
Sample solution is provided at 25 µL, 10mM.
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Docetaxel-d9 is intended for use as an internal standard for the quantification of docetaxel by GC- or LC-MS. Docetaxel is a semisynthetic analog of paclitaxel that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM).1 It has proven more effective than taxol in preventing the proliferation of cancer cells.1,2 Docetaxel has potential applications in breast cancer and hormone-refractory prostate cancer.3,4
1.Bissery, M.C., Guenard, D., Gueritte-Voegelein, F., et al.Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogueCancer Research514845-4852(1991) 2.Pazdur, R., Kudelka, A.P., Kavanagh, J.J., et al.The taxoids: Paclitaxel (Taxolr) and docetaxel (Taxoterer)Cancer Treatment Reviews19351-386(1993) 3.Mahon, K.L., Henshall, S.M., Sutherland, R.L., et al.Pathways of chemotherapy resistance in castration-resistant prostate cancerEndocrine-Related Cancer18R103-R123(2011) 4.Yao, X., Hosenpud, J., Chitambar, C.R., et al.A phase II study of concurrent docetaxel, epirubicin and cyclophospha-mide as a neoadjuvant chemotherapy regimen in patients with locally advanced breast cancerJournal of Cancer3145-151(2012)
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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