Mycophenolate Mofetil-d4 (Synonyms: MMF-d4) |
| Catalog No.GC47712 |
Mycophenolate Mofetil-d4는 Mycophenolate Mofetil이라고 표시된 중수소입니다. 미코페놀레이트 모페틸(RS 61443)은 미코페놀산의 모르폴리노에틸에스테르 전구약물입니다. Mycophenolate mofetil은 IMPDH(inosine monophosphate dehydrogenase)의 억제를 통해 새로운 퓨린 합성을 억제합니다. Mycophenolate mofetil은 T 세포와 B 세포를 모두 포함하여 항체 형성을 방지하는 선택적 림프구 항증식 효과를 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1132748-21-0
Sample solution is provided at 25 µL, 10mM.
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Mycophenolate mofetil-d4 is intended for use as an internal standard for the quantification of mycophenolate mofetil by GC- or LC-MS. Mycophenolate mofetil is a prodrug form of mycophenolic acid .1,2,3 In vivo, mycophenolate mofetil (12.5 mg/kg) increases duration of transplant motor activity in a rabbit model of retroperitoneal heterotopic heart transplantation.1 It eliminates formation of microbleeds and hemorrhages in the cerebrum of stroke-prone spontaneously hypertensive rats.2 Mycophenolate mofetil also lowers mean arterial pressure (MAP) and reduces urinary albumin excretion and glomerulosclerosis, markers of renal damage, in a mouse model of systemic lupus erythematosus (SLE).3
1.AygÜn, F., Efe, D., and Durgut, K.Comparison of MMF with prednisone in terms of rejection and duration of activity of transplant in rabbits that underwent retroperitoneal heterotopic heart transplantationCardiovasc. J. Afr.26(3)104-108(2015) 2.Dhande, I.S., Zhu, Y., Braun, M.C., et al.Mycophenolate mofetil prevents cerebrovascular injury in stroke-prone spontaneously hypertensive ratsPhysiol. Genomics49(3)132-140(2017) 3.Taylor, E.B., and Ryan, M.J.Immunosuppression with mycophenolate mofetil attenuates hypertension in an experimental model of autoimmune diseaseJ. Am. Heart Assoc.6(3)e005394(2017)
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