INNO-8875 (Synonyms: PJ 875, Trabodenoson) |
| Catalog No.GC48621 |
아데노신 모방체인 INNO-8875(INO-8875)는 고도로 선택적인 아데노신 A1 수용체 작용제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 871108-05-3
Sample solution is provided at 25 µL, 10mM.
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INNO-8875 is an adenosine A1 receptor agonist.1,2 It binds to adenosine A1 receptors (Ki = 0.97 nM) and is greater than 10,000-fold selective for adenosine A1 over A2 receptors. Topical application of INNO-8875 (25 µg/eye) reduces intraocular pressure in a rabbit model of ocular hypertension.2 INNO-8875 (1-50 µg/kg) decreases atrial refractoriness and heart rate, as well as slows atrioventricular nodal conduction, in anesthetized rats.1
1.Mor, M., Shalev, A., Dror, S., et al.INO-8875, a highly selective A1 adenosine receptor agonist: Evaluation of chronotropic, dromotropic, and hemodynamic effects in ratsJ. Pharmacol. Exp. Ther.344(1)59-67(2012) 2.Kim, N., Crosson, C., Supuran, C., et al.INO-8875, an adenosine A1 agonist, in development for open-angle glaucoma reduces IOP in three rabbit modelsInvert. Ophthalmol. Vis. Sci.50(13)4061(2009)
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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