INNO-8875 (Synonyms: PJ 875, Trabodenoson) |
| Katalog-Nr.GC48621 |
INNO-8875 (INO-8875), ein Adenosin-Mimetikum, ist ein hochselektiver Adenosin-A1-Rezeptor-Agonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 871108-05-3
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
INNO-8875 is an adenosine A1 receptor agonist.1,2 It binds to adenosine A1 receptors (Ki = 0.97 nM) and is greater than 10,000-fold selective for adenosine A1 over A2 receptors. Topical application of INNO-8875 (25 µg/eye) reduces intraocular pressure in a rabbit model of ocular hypertension.2 INNO-8875 (1-50 µg/kg) decreases atrial refractoriness and heart rate, as well as slows atrioventricular nodal conduction, in anesthetized rats.1
1.Mor, M., Shalev, A., Dror, S., et al.INO-8875, a highly selective A1 adenosine receptor agonist: Evaluation of chronotropic, dromotropic, and hemodynamic effects in ratsJ. Pharmacol. Exp. Ther.344(1)59-67(2012) 2.Kim, N., Crosson, C., Supuran, C., et al.INO-8875, an adenosine A1 agonist, in development for open-angle glaucoma reduces IOP in three rabbit modelsInvert. Ophthalmol. Vis. Sci.50(13)4061(2009)
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *