10-hydroxy Warfarin |
| Catalog No.GC49118 |
A metabolite of (R)-warfarin
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 83219-99-2
Sample solution is provided at 25 µL, 10mM.
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10-hydroxy Warfarin is a metabolite of (R)-warfarin .1 It is formed from (R)-warfarin by the cytochrome P450 (CYP) isoform CYP3A4. 10-hydroxy Warfarin is an inhibitor of CYP2C9 (IC50 = 1.6 µM), the enzyme that converts (S)-warfarin to its 6-hydroxy warfarin and 7-hydroxy warfarin metabolites.2
1.Kaminsky, L.S., and Zhang, Z.-Y.Human P450 metabolism of warfarinPharmacol. Ther.73(1)67-74(1997) 2.Jones, D.R., Kim, S.-Y., Guderyon, M., et al.Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarinChem. Res. Toxicol.23(5)939-945(2010)
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