>>Signaling Pathways>> Tyrosine Kinase>> Spleen Tyrosine Kinase (Syk)>>R788 disodium hexahydrate

R788 disodium hexahydrate

Catalog No.GC15709

포스타마티닙(R788) 이나트륨 육수화물은 활성 화합물 R406의 경구 전구약물입니다.

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R788 disodium hexahydrate Chemical Structure

Cas No.: 914295-16-2

Size 가격 재고 수량
5mg
US$91.00
재고 있음
10mg
US$133.00
재고 있음
50mg
US$314.00
재고 있음
100mg
US$560.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Fostamatinib disodium hexahydrate (R788 disodium hexahydrate), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.

References:
[1]. Braselmann, S., et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther, 2006. 319(3): p. 998-1008.
[2]. Chen, L., et al., SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood, 2008. 111(4): p. 2230-7.
[3]. Suljagic, M., et al., The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling. Blood, 2010. 116(23): p. 4894-905.

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