DC_517 |
| Catalog No.GC32872 |
DC_517은 IC50 및 Kd가 각각 1.7μM 및 0.91μM인 DNA 메틸트랜스퍼라제 1(DNMT1) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 500017-70-9
Sample solution is provided at 25 µL, 10mM.
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DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively.
DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively. DC_517 (1.25, 2.5, 5, and 10 μM) potently inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC_517 (0, 0.75, 1.5, and 3 μM) also dose-dependently induces apoptotic cell death in HCT116 cells[1].
[1]. Chen S, et al. Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem. 2014 Nov 13;57(21):9028-9041.
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