Endovion (Synonyms: NS3728) |
| Catalog No.GC34574 |
Endovion(NS3728)은 약리학적 음이온 채널 억제제(염화물 채널과 같은) 및 특정 VRAC/VSOAC 차단제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 265646-85-3
Sample solution is provided at 25 µL, 10mM.
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Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor[1][2]. Chloride channel, VRAC/VSOAC[1]. ANO1[2].
[1]. S?rensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73. [2]. Sauter DR, et al. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-1508.
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