Ursodeoxycholic Acid (sodium salt) (Synonyms: UDCA, Ursodiol) |
| Catalog No.GC45132 |
우르소데옥시콜산(우르소데옥시콜레이트) 나트륨은 장내 세균에 의한 (체노)데옥시콜산의 변형으로 인해 생성되는 2차 담즙산으로, 장 장벽 완전성의 핵심 조절자 역할을 하며 지질 대사에 필수적입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2898-95-5
Sample solution is provided at 25 µL, 10mM.
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Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid . UDCA is also a metabolite of lithocholic acid in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.
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