Ursodeoxycholic Acid (sodium salt) (Synonyms: UDCA, Ursodiol) |
| カタログ番号GC45132 |
ウルソデオキシコール酸（ウルソデオキシコール酸）ナトリウムは、腸内細菌による（ケノ）デオキシコール酸の変換から生じる二次胆汁酸であり、腸バリアの完全性の重要な調節因子として作用し、脂質代謝に不可欠です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2898-95-5
Sample solution is provided at 25 µL, 10mM.
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Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid . UDCA is also a metabolite of lithocholic acid in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.
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