CAY10397 (Synonyms: CK47A) |
| Catalog No.GC18549 |
Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 78028-01-0
Sample solution is provided at 25 µL, 10mM.
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Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). This enzyme oxidizes the 15-hydroxyl group and hydrogenates the 13,14-double bond, producing 13,14-dihydro-15 keto metabolites with greatly reduced biological activity. CAY10397 is a selective inhibitor of 15-hydroxy PGDH with an IC50 of approximately 10 uM. CAY10397 acts to prolong the lifetime and activity of endogenously produced prostaglandins both in cell culture and in vivo.
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Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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