CAY10397 (Synonyms: CK47A) |
| Katalog-Nr.GC18549 |
Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 78028-01-0
Sample solution is provided at 25 µL, 10mM.
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Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). This enzyme oxidizes the 15-hydroxyl group and hydrogenates the 13,14-double bond, producing 13,14-dihydro-15 keto metabolites with greatly reduced biological activity. CAY10397 is a selective inhibitor of 15-hydroxy PGDH with an IC50 of approximately 10 uM. CAY10397 acts to prolong the lifetime and activity of endogenously produced prostaglandins both in cell culture and in vivo.
Review for CAY10397
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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