CAY10640 (Synonyms: sEHi, Soluble Epoxide Hydrolase Inhibitor) |
| Catalog No.GC18887 |
CAY10640(화합물 TCPU)은 인간과 쥐에서 각각 IC50이 0.4 및 5.3nM인 sEH(용해성 에폭시드 가수분해효소)의 강력한 경구 활성 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1208549-68-1
Sample solution is provided at 25 µL, 10mM.
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Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM. CAY10640 demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model.
Review for CAY10640
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for CAY10640
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