Chlortetracycline (Synonyms: 7-Chlortetracycline) |
| Catalog No.GC40996 |
Chlorotetracycline(7-Chlorotetracycline)은 특이적이고 강력한 칼슘 이온통로구(ionophore) 항생제로 아미노아실-tRNA가 리보솜에 결합하는 것을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 57-62-5
Sample solution is provided at 25 µL, 10mM.
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Chlortetracycline is a broad-spectrum antibiotic originally isolated from S. aureofaciens. It inhibits growth of both Gram-positive and Gram-negative bacteria at a range of 0.1-100 μg/ml against A. aerogenes, D. pneumoniae, E. coli, K. pneumoniae, P. morganii, and several species of Haemophilus, Neisseria, Salmonella, and Staphylococcus. Chlortetracycline protects mice from infection by various strains of S. aureus with protective doses (PD50s) of 0.2-7.5 mg/kg, and from infection by E. coli (PD50 = 3 mg/kg) and K. pneumoniae (PD50 = 75 mg/kg). It acts by inhibiting protein synthesis, and it binds to a single site on the 30S ribosome subunit. Chlortetracycline is an ionophore and is selective for calcium over sodium, potassium, magnesium, strontium, and barium. It transports calcium from an aqueous phase into an organic phase environment or into multilamellar vesicles. Chlortetracycline is also a fluorescent dye that can be used to monitor calcium flux.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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