Clinafloxacin (hydrochloride) (Synonyms: AM1091) |
Catalog No.GC13259 |
Clinafloxacin(염산염)(AM 1091 염산염)은 강력하고 광범위한 스펙트럼의 플루오로퀴놀론 항생제이며 시험관 내에서 그람 양성균, 그람 음성균 및 혐기성 병원체에 대한 억제 활성을 가지고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 105956-99-8
Sample solution is provided at 25 µL, 10mM.
Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.
In selected volunteer subjects and patients, after the administration of oral and intravenous doses of racemic drug, the clinafloxacin showed a broad-spectrum antibiotic of the quinolone carboxylic acid category. The absorption of the clinafloxacin enantiomer was rapid after oral 400 mg dose and 400 mg intravenous dose of racemic drug [1]. Clinafloxacin showed high activity against S. pneumoniae 7785 with the MIC value of 0.125 μg/ml. Clinafloxacin showed potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens [2]. Clinafloxacin has been identified as the most active fluoroquinolone against S. pneumoniae compared to grepafloxacin, levofloxacin, ofloxacin, sparfloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3].
References:
[1]. Humphrey G H, Shapiro M A, Randinitis E J, et al. Pharmacokinetics of clinafloxacin enantiomers in humans[J]. The Journal of Clinical Pharmacology, 1999, 39(11): 1143-1150.
[2]. Pan X S, Fisher L M. DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae[J]. Antimicrobial Agents and Chemotherapy, 1998, 42(11): 2810-2816.
[3]. Jorgensen J H, Weigel L M, Swenson J M, et al. Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae[J]. Antimicrobial agents and chemotherapy, 2000, 44(11): 2962-2968.
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