D-α-Tocopheryl Quinone (Synonyms: α-Tocopherylquinone, α-Tocoquinone, α-TQ, Tocopherol Quinone) |
Catalog No.GC49868
One-Click Copy Product Info
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An oxidative metabolite of vitamin E
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 7559-04-8
Sample solution is provided at 25 µL, 10mM.
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D-α-Tocopheryl quinone is an active oxidative metabolite of vitamin E and an essential cofactor for mitochondrial fatty acid desaturases.1 It has antioxidant activity in oxygen radical absorbance capacity (ORAC) and radical trapping assays when used at a concentration of 25 µM and inhibits ferroptosis induced by (1S,3R)-RSL3 in Q7 cells (EC50 = 0.233 µM).2 D-α-Tocopheryl quinone (20 mg/kg) decreases serum malondialdehyde (MDA) and blood glucose levels and restores the number and diversity of intestinal microflora in a rat model of high cholesterol and cholate diet-induced non-alcoholic steatohepatitis (NASH).3
1.Infante, J.P.A function for the vitamin E metabolite alpha-tocopherol quinone as an essential enzyme cofactor for the mitochondrial fatty acid desaturasesFEBS Lett.446(1)1-5(1999) 2.Hinman, A., Holst, C.R., Latham, J.C., et al.Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.PLoS One13(8)e0201369(2018) 3.Sun, T., Zhang, B., Ru, Q.-J., et al.Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) via restoring the balance of intestinal flora in ratsPharm. Biol.59(1)723-731(2021)
| Cas No. | 7559-04-8 | SDF | |
| Synonyms | α-Tocopherylquinone, α-Tocoquinone, α-TQ, Tocopherol Quinone | ||
| Canonical SMILES | CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@@](C)(O)CCC1=C(C(C(C)=C(C1=O)C)=O)C | ||
| Formula | C29H50O3 | M.Wt | 446.7 |
| Solubility | DMF: 12 mg/mL,DMSO: 10 mg/mL,Ethanol: 16 mg/mL | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2386 mL | 11.1932 mL | 22.3864 mL |
| 5 mM | 447.7 μL | 2.2386 mL | 4.4773 mL |
| 10 mM | 223.9 μL | 1.1193 mL | 2.2386 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A liquid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)