DDR1-IN-5 |
| Catalog No.GC65378 |
DDR1-IN-5는 IC50이 7.36nM인 선택적 디스코이딘 도메인 수용체 계열, 구성원 1(DDR1) 억제제입니다. DDR1-IN-5는 4.1nM의 IC50으로 자동 인산화 DDR1b(Y513)를 억제합니다. DDR1-IN-5는 항암 활성이 있습니다.
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Cas No.: 2416022-90-5
Sample solution is provided at 25 µL, 10mM.
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DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity[1].
DDR1-IN-5 (compound 121; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=62 nM)[1]. DDR1-IN-5 (72 hours) has cytotoxicity in LX-2 cells (CC50>40 μM)[1].
[1]. Aleksandr M. Aliper, et al. Kinase inhibitors. WO2020079652A1.
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