Deferitrin (Synonyms: GT-56-252, (S)-4'-Hydroxydesazadesferrithiocin) |
| Catalog No.GC52316 |
An iron chelator and derivative of desferrithiocin
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 239101-33-8
Sample solution is provided at 25 µL, 10mM.
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Deferitrin is an iron chelator and a derivative of desferrithiocin that binds iron in a 2:1 (ligand:iron) ratio.1,2 It inhibits the proliferation of L1210 murine leukemia cells (IC50 = 17 µM).3 Deferitrin (150 µmol/kg) induces iron excretion in iron-overloaded C. apella monkeys and beagle dogs with an iron clearing efficiency (ICE) of 14.5 and 9.3%, respectively.2 It reduces fecal and urine iron levels by 607 and 357 µg/kg in C. apella monkeys and beagle dogs, respectively.
1.Bergeron, R.J., Wiegand, J., Bharti, N., et al.Desferrithiocin analogue iron chelators: Iron clearing efficiency, tissue distribution, and renal toxicityBiometals24(2)239-258(2011) 2.Bergeron, R.J., Wiegand, J., Weimar, W.R., et al.Comparison of iron chelator efficacy in iron-overloaded beagle dogs and monkeys (Cebus apella)Comp. Med.54(6)664-672(2004) 3.Bergeron, R.J., Wiegand, J., Weimar, W.R., et al.Iron chelation promoted by desazadesferrithiocin analogs: An enantioselective barrierChirality15(7)593-599(2003)
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