E3 ligase Ligand 2 (Synonyms: 4-hydroxy Thalidomide) |
| Catalog No.GC32848 |
E3 리가제 리간드 2(Cereblon 리간드 2)는 CRBN 단백질 모집에 사용되는 탈리도마이드 기반 세레블론 리간드입니다. E3 리가제 리간드 2(Cereblon 리간드 2)는 링커에 의해 단백질용 리간드에 연결되어 PROTAC를 형성할 수 있습니다.
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Cas No.: 5054-59-1
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology.
Thalidomide may exert anti-angiogenic effect in isolated blood vessels and endothelial cells. E3 ligase Ligand 2 is a putative hydroxylated thalidomide metabolite. E3 ligase Ligand 2 has weak anti-angiogenic activity (14% mean inhibition of blood vessel density at 100 mg). E3 ligase Ligand 2 does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells[1].
[1]. Marks MG, et al. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May;25(5):597-604.
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