Envonalkib |
| Catalog No.GC65380 |
Envonalkib은 WT에 대해 IC50이 1.96nM, 35.1nM, 61.3nM이고 돌연변이된 L1196M 및 G1269S-ALK에 대해 ALK의 강력한 경구 활성 억제제입니다. Envonalkib은 비소세포폐암 연구에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1621519-26-3
Sample solution is provided at 25 µL, 10mM.
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Envonalkib is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib can be used for the research of non-small cell lung cancer[1].
Envonalkib (formula I) (12.5-25 mg/kg; p.o. once daily for 14 days) inhibits the growth of human non-small cell lung cancer NCI-H2228 nude mice xenografts[1].
[1]. Feng G, et, al. Pyridine-substituted 2-aminopyridine protein kinase inhibitors. WO2016015676A1.
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