Erianin (Synonyms: NSC 613744) |
| Catalog No.GC30309 |
해열제 및 진통제로 자주 사용되는 Erianin은 IDO 유발 종양 혈관 신생을 억제할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 95041-90-0
Sample solution is provided at 25 µL, 10mM.
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Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.
Erianin is often used as antipyretic and analgesic agent. Erianin belongs to bibenzyl derivatives in structure, with the activity of anti-virus, anti-bacterial, as well as anti-benign prostatic hyperplasia. Erianin has obvious damage on 2LL-IDO cells, Erianin basically has no cytotoxicity on human normal liver cell line L02, and cell viability is maintained at around 85%[1]. Erianin inhibits the growth of HeLa cells and induces apoptosis in a dose? and time?dependent manner, inducing cell cycle arrest at the G2/M stage. Erianin treatment also increases the expression of Bax and caspase?3, but decreases levels of Bcl?2 and phosphorylated?ERK1/2[2].
[1]. Su C, et al. Erianin inhibits indoleamine 2, 3-dioxygenase -induced tumor angiogenesis. Biomed Pharmacother. 2017 Apr;88:521-528. [2]. Li M, et al. Erianin inhibits human cervical cancer cell through regulation of tumor protein p53 via the extracellular signal-regulated kinase signaling pathway. Oncol Lett. 2018 Oct;16(4):5006-5012.
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