ERRα antagonist-1 |
| Catalog No.GC38777 |
ERRα 길항제-1(화합물 A)은 선택적 고친화성 에스트로겐 관련 수용체 α(ERRα) 길항제입니다. ERRα 길항제-1은 ERRα와 증식자 활성화 수용체 γ Coactivator-1α(PGC-1α) 및 PGC-1β의 상호작용을 억제하며, IC50 값은 각각 170nM 및 180nM입니다. ERRα 길항제-1은 ERRβ 또는 ERRγ와 PGC-1α 및 PGC-1β 보조 활성화제의 상호 작용을 억제하지 않으며 ERα 또는 ERβ와 PGC-1α 또는 SRC-1의 상호 작용도 억제하지 않습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1072145-33-5
Sample solution is provided at 25 µL, 10mM.
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ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1[1].
[1]. Michael J. Chisamore, et al. Identification of Small Molecule Estrogen-Related
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