Farnesyl Thiosalicylic Acid Amide (Synonyms: FTS Amide,Salirasib Amide) |
Catalog No.GC15555
One-Click Copy Product Info
|
inhibits tumor growth
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1092521-74-8
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
IC50: 20 and 10 μM for the growth of PANC-1 and U87 tumor cells, respectively
Farnesyl thiosalicylic acid amide (FTS-A), an farnesyl thiosalicylic acid derivative, inhibits tumor growth.
Farnesylthiosalicylic acid (FTS, Salirasib), a Ras inhibitor, can interfer with Ras membrane interactions that are crucial for Ras-dependent transformation.
In vitro: Previous study examined the effects of the FTS-A and its two analogs (FTS-MA and FTS-DMA) on panc-1 and U87 cells and the results showed that all three FTS-amides caused a dose-dependent decrease in cell number of both cell lines exhibiting similar potencies. Cell death was observed at concentrations higher than 50 μM. The IC50s recorded in both cell lines were at the range of 10-20 μM. FTS-A, FTS-MA, and FTS-DMA caused a clear decrease in the levels of K-Ras-GTP in Panc-1 cells and in U87 cells. Reduction in the level of N-Ras-GTP was observed only in U87 cells and no effect on H-Ras-GTP was observed in either cell line [1].
In vivo: The effect of FTS-A on brain tumor growth was examined using a nude mouse model with human glioblastoma U87 cells intracranially implanted into the striatum area. FTS-A at 100 mg/kg was administered orally twice daily. Results showed that the increase in tumor volume recorded over time in the FTS-A treated mouse was significantly lower than that recorded in the control mouse. Moreover, it was found that more contrast agent molecules accumulated in the control mice as compared to the FTS-A treated mice. In addition, this study did not see any inflammatory response in the brains of the controls or in the brains of FTS-A-treated mice [1].
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Goldberg, L. ,Haklai, R.,Bauer, V., et al. New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: Farnesylthiosalicylamide inhibits tumor growth in nude mice models. Journal of Medicinal Chemistry 52, 197-205 (2009).
| Cas No. | 1092521-74-8 | SDF | |
| Synonyms | FTS Amide,Salirasib Amide | ||
| Chemical Name | 2-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]thio]-benzamide | ||
| Canonical SMILES | C\C(CC/C=C(CC/C=C(C)\C)\C)=C/CSC1=C(C(N)=O)C=CC=C1 | ||
| Formula | C22H31NOS | M.Wt | 357.6 |
| Solubility | DMF: 12 mg/ml,DMSO: 10 mg/ml,Ethanol: 20 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.7964 mL | 13.9821 mL | 27.9642 mL |
| 5 mM | 559.3 μL | 2.7964 mL | 5.5928 mL |
| 10 mM | 279.6 μL | 1.3982 mL | 2.7964 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >96.00% Appearance: A solution in ethanol
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)