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FDI-6 (Synonyms: FDI-6, Forkhead Domain Inhibitory Compound 6, NCGC00099374)

Catalog No.GC32972

FDI-6은 FOXM1의 억제제입니다. FDI-6은 FOXM1 단백질에 직접 결합하여 MCF-7 유방암 세포의 게놈 표적에서 FOXM1을 대체하고 수반되는 전사 하향 조절을 유도합니다.

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FDI-6 Chemical Structure

Cas No.: 313380-27-7

Size 가격 재고 수량
10mM (in 1mL DMSO)
US$95.00
재고 있음
5mg
US$86.00
재고 있음
10mg
US$158.00
재고 있음
25mg
US$308.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

FDI-6 is an inhibitor of FOXM1. FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation.

FDI-6 is characterized in depth and is shown to bind directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation. MDA-MB-231 ER-negative breast and PEO-1 ovarian cancer cells are sensitive to FDI-6 in cell viability assays (GI50=21.8 μM and 18.1 μM, respectively) and exhibit comparable down-regulation of CDC25B after a 3 h treatment with FDI-6. The transcription factor FOXM1 regulates a network of proliferation-associated genes critical to mitotic spindle assembly, chromosome segregation, and G2/M transition, with depletion leading to cell cycle arrest. Importantly, aberrant up-regulation of FOXM1 has been shown to be a key driver of cancer progression and has been proposed as an initiating factor of oncogenesis[1].

[1]. Gormally MV, et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 2014 Nov 12;5:5165.

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