Fmoc-Ala-Glu-Asn-Lys-NH2 |
| Catalog No.GC61476 |
Fmoc-Ala-Glu-Asn-Lys-NH2는 선택적 아스파라긴 엔도펩티다제(AEP) 억제제 펩티드이며 아밀로이드 전구체 단백질(APP) 절단을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 220701-06-4
Sample solution is provided at 25 µL, 10mM.
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Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].
Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].
[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.
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