Diphenyldiazomethane resin (200-400 mesh, 0.7-1.3 mmol/g) |
| Catalog No.GA21381 |
Diphenyldiazomethane was used industrially for producing benzhydryl esters (diphenylmethyl esters) of β-lactam antibiotics. This "polymeric diphenyldiazomethane" readily reacts with carboxylic acids, e.g. Fmoc-amino acids, which need not to be activated. Products can be cleaved from this very acid-sensitive resin derivative with 1-5 % TFA in dichloromethane. Fmoc-α-amino alcohols can be anchored to PDDM in the presence of BF? etherate. As the resulting benzhydryl ethers can be cleaved with 1% TFA/DCM, fully protected peptide alcohols can be obtained.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Diphenyldiazomethane was used industrially for producing benzhydryl esters (diphenylmethyl esters) of β-lactam antibiotics. This "polymeric diphenyldiazomethane" readily reacts with carboxylic acids, e.g. Fmoc-amino acids, which need not
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