H-Arg-Arg-OH |
Catalog No.GA22068
One-Click Copy Product Info
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H-Arg-Arg-OH는 펩타이드 결합으로 연결된 두 개의 아르기닌 분자로 구성된 염기성 디펩타이드이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 15483-27-9
Sample solution is provided at 25 µL, 10mM.
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H-Arg-Arg-OH는 펩타이드 결합으로 연결된 두 개의 아르기닌 분자로 구성된 염기성 디펩타이드이다. 생리학적 조건에서 H-Arg-Arg-OH는 강한 양전하를 띠고 우수한 수용성을 보유해서 특정한 효소 절단 부위를 가지고 있다[2]. H-Arg-Arg-OH는 트립신과 같은 세린 프로테아제의 전형적인 특이적 기질이고 효소 동역학 연구 및 효소 활성 분석에 일반적으로 사용된다. 그 강한 염기적 특성은 또한 양이온 펩타이드와 생물학적 막 사이의 상호작용을 연구하는 모델 분자로 만들어 준다[2]. H-Arg-Arg-OH는 생화학 연구, 효소 실험 및 폴리펩타이드 합성의 중간체나 기준 표준물질로 적합하다[3, 4].
References:
[1] Atkinson C E, Aliev A E, Motherwell W B. Binding site optimisation for artificial enzymes by diffusion NMR of small molecules[J]. Chemistry–A European Journal, 2003, 9(8): 1714-1723.
[2] Smiljanic E. Some studies of artificial enzyme systems[M]. University of London, University College London (United Kingdom), 2006.
[3] Lee Y, Yang J, Rudich S M, et al. Improved planar amperometric nitric oxide sensor based on platinized platinum anode. 2. Direct real-time measurement of NO generated from porcine kidney slices in the presence of L-arginine, L-arginine polymers, and protamine[J]. Analytical chemistry, 2004, 76(3): 545-551.
[4] Arendt M, Sun W, Thomann J, et al. Dendrimeric bisphosphonates for multivalent protein surface binding[J]. Chemistry–An Asian Journal, 2006, 1(4): 544-554.
| Cas No. | 15483-27-9 | SDF | |
| Formula | C12H26N8O3 | M.Wt | 330.39 |
| Solubility | 10mg/ml in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.0267 mL | 15.1336 mL | 30.2673 mL |
| 5 mM | 605.3 μL | 3.0267 mL | 6.0535 mL |
| 10 mM | 302.7 μL | 1.5134 mL | 3.0267 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)