Z-Phe-Phe-Phe-OH |
Catalog No.GA23911
One-Click Copy Product Info
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Z-Phe-Phe-Phe-OH는 트리펩타이드로서 세포막이나 바이러스 포막과 상호작용하여 지질 이중층의 융합 과정을 방해하여 바이러스가 숙주세포에 들어가거나 세포 간 융합을 억제하는 역할을 한다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 57092-52-1
Sample solution is provided at 25 µL, 10mM.
Z-Phe-Phe-Phe-OH는 트리펩타이드로서 세포막이나 바이러스 포막과 상호작용하여 지질 이중층의 융합 과정을 방해하여 바이러스가 숙주세포에 들어가거나 세포 간 융합을 억제하는 역할을 한다. Z-Phe-Phe-Phe-OH는 3개의 페닐알라난(Phe) 유전자가 펩타이드결합을 통해 순차적으로 연결되어 있으며 N-단에는 벤질옥시카르보닐(Z-) 보호기단이 있다. 페닐알라난은 측면 사슬에 벤질 고리가 있는 아로매틱 아미노산으로 이는 그것을 매우 기름기 있으며 단단하게 만든다[3]. 벤질옥시카르보닐 보호그룹의 도입은 트리펩타이드에 추가적인 안정성을 제공하며 실험 과정에서 분해될 확률을 낮춘다[4]. 이 제품의 분자식은 C35H35N3O6이고 분자량은 593.68이다.
References:
[1] Zheng C, Zhong Q, Song W, et al. Membrane‐Fusion‐Mediated Multiplex Engineering of Tumor Cell Surface Glycans for Enhanced NK Cell Therapy[J]. Advanced Materials, 2023, 35(14): 2206989.
[2] Kong H, Zheng C, Yi K, et al. An antifouling membrane-fusogenic liposome for effective intracellular delivery in vivo[J]. Nature Communications, 2024, 15(1): 4267.
[3] Das T, Häring M, Haldar D, et al. Phenylalanine and derivatives as versatile low-molecular-weight gelators: Design, structure and tailored function[J]. Biomaterials science, 2018, 6(1): 38-59.
[4] Bochet C G. Photolabile protecting groups and linkers[J]. Journal of the Chemical Society, Perkin Transactions 1, 2002 (2): 125-142.
| Cas No. | 57092-52-1 | SDF | |
| Formula | C35H35N3O6 | M.Wt | 593.68 |
| Solubility | 100mg/ml in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.6844 mL | 8.422 mL | 16.8441 mL |
| 5 mM | 336.9 μL | 1.6844 mL | 3.3688 mL |
| 10 mM | 168.4 μL | 842.2 μL | 1.6844 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)