ASP6432 |
Catalog No.GC35409 |
ASP6432는 인간 LPA1 및 쥐 LPA1에 대해 각각 11nM 및 30nM의 IC50을 갖는 강력하고 선택적인 유형 1 리소포스파티딘산 수용체(LPA1) 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1282549-08-9
Sample solution is provided at 25 µL, 10mM.
ASP6432 is a potent and selective type 1 lysophosphatidic acid receptor (LPA1) antagonist with IC50s of 11 nM and 30 nM for human LPA1 and rat LPA1, respectively[1]. IC50: 11 nM (human LPA1), 30 nM (rat LPA1)[1]
ASP6432 inhibits the LPA-induced proliferation of human prostate stromal cells[1].
[1]. Sakamoto K, et al. Effect of ASP6432, a Novel Type 1 Lysophosphatidic Acid Receptor Antagonist, on Urethral Function and Prostate Cell Proliferation. J Pharmacol Exp Ther. 2018 Aug;366(2):390-396.
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