BMS-906024 |
| Catalog No.GC35535 |
BMS-906024는 경구 활성 및 선택적 γ-secretase(감마 세크레타제) 억제제입니다. BMS-906024는 Notch1, -2, -3 및 -4 수용체에 대해 IC50이 각각 1.6nM, 0.7nM, 3.4nM 및 2.9nM인 강력한 범-노치 수용체 억제제입니다. BMS-906024는 광범위한 항종양 활성을 보여줍니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1401066-79-2
Sample solution is provided at 25 µL, 10mM.
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BMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor[1]. BMS-906024 prevents the activation of all four Notch receptors with a high oral bioavailability with IC50s of 1.6, 0.7, 3.4, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity against a wide array of human cancer xenografts[2]. IC50: 1.6 nM (Notch1), 0.7 nM (Notch2), 3.4 nM (Notch3) and 2.9 nM (Notch4)[2]
[1]. Morgan KM, et al. Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma. Mol Cancer Ther. 2017 Dec;16(12):2759-2769. [2]. Gavai AV, et al. Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors. ACS Med Chem Lett. 2015 Mar 11;6(5):523-7.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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