Cdc7-IN-1 |
| Catalog No.GC35628 |
Cdc7-IN-1(화합물 13)은 1mM ATP에서 IC50 값이 0.6nM이고 느린 오프 속도 특성을 갖는 Cdc7 키나제의 매우 강력하고 선택적이며 ATP 경쟁적인 억제제입니다. Cdc7-IN-1은 암세포에서 Cdc7 활성을 강력하게 억제하고 효과적으로 세포 사멸을 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1402055-25-7
Sample solution is provided at 25 µL, 10mM.
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Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death[1]. IC50: 0.6 nM (Cdc7, at 1 mM ATP)[1]
[1]. Irie T, et al. Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. Eur J Med Chem. 2017 Apr 21;130:406-418.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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