E-6123 |
| Catalog No.GC35922 |
E-6123은 혈소판 활성화 인자(PAF) 수용체 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 131614-02-3
Sample solution is provided at 25 µL, 10mM.
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E-?6123 is a platelet-activating factor (PAF) receptor antagonist. PAF[1]
E-6123 (E6123) partially inhibits the Thapsigargin-induced increase in the levels of interleukin-6 mRNA and interleukin-6 protein. To clarify the role of the concurrently produced cell-associated PAF in the thapsigargin-induced increase in the interleukin-6 mRNA level and interleukin-6 production, the effects of the PAF receptor antagonist E-6123 are examined. E-6123 at 1 and 10 μM partially inhibits the Thapsigargin (46.1 nM)-induced increase in the interleukin-6 mRNA level at 4 h and interleukin-6 production at 8 h[1].
[1]. Ichinowatari G, et al. Participation of prostaglandin E2 and platelet-activating factor in thapsigargin-induced production of interleukin-6. Eur J Pharmacol. 2002 Jan 11;434(3):187-96.
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