JNJ-37822681 dihydrochloride |
| Catalog No.GC36370 |
JNJ-37822681 디히드로클로라이드는 도파민 D2L 수용체(Ki = 158 nM)에 대해 적당한 결합 친화도를 갖는 강력하고 특이적이며 중추 활성이며 빠르게 해리되는 도파민 D2 수용체 길항제이며, 이는 정신분열병 및 양극성 장애의 치료 가능성이 있습니다[1 ].
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2108806-02-4
Sample solution is provided at 25 µL, 10mM.
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JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder[1]. Ki: 158 nM (dopamine D(2))[1]
[1]. Langlois X, et al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J Pharmacol Exp Ther. 2012 Jul;342(1):91-105.
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