LIN28 inhibitor LI71 |
| Catalog No.GC36464 |
LIN28 억제제 LI71은 7 uM의 IC50으로 LIN28 매개 올리고우리딜화를 제거하는 강력하고 세포 투과성인 LIN28 억제제입니다. LIN28 억제제 LI71은 CSD(cold shock domain)에 직접 결합하여 백혈병 세포와 배아줄기세포에서 let-7에 대한 LIN28의 활성을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1357248-83-9
Sample solution is provided at 25 µL, 10mM.
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LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM. LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28's activity against let-7 in leukemia cells and embryonic stem cells[1]. IC50: 7 uM (LIN28)[1]
[1]. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 Jun 5;23(10):3091-3101.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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