LY-2940094 (Synonyms: BTRX-246040) |
| Catalog No.GC36508 |
LY-2940094(BTRX-246040)는 높은 친화도(Ki\u003d0.105nM) 및 길항제 효능(Kb\u003d0.166nM)을 갖는 강력하고 선택적이고 경구적으로 이용 가능한 노시셉틴 수용체(NOP 수용체) 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1307245-86-8
Sample solution is provided at 25 µL, 10mM.
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LY-2940094 is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY-2940094 reduces ethanol self-administration in animal models[1]. Ki: 0.105 nM (NOP receptor)[1]Kb: 0.166 nM (NOP receptor)[1]
LY-2940094 (LY2940094; 3, 10, or 30 mg/kg; 2-3 mL/kg; orally daily; for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity[1]. Animal Model: Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)[1]
[1]. Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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