Mc-MMAE |
Catalog No.GC36561 |
Mc-MMAE는 강력한 튜불린 억제제인 보호기(말레이미도카프로일)-결합 모노메틸 아우리스타틴 E(MMAE)입니다. Mc-MMAE는 ADC에 대한 약물-링커 접합체입니다.
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Cas No.: 863971-24-8
Sample solution is provided at 25 µL, 10mM.
Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a drug-linker conjugate for ADC. Tubulin, Antibody-drug conjugates (ADC)[1]
Synthesis of maleimidocaproyl-MMAE (mc-MMAE) requires the addition of maleimidocaproic acid to a solution of MMAE in dichloromethane followed by the addition of diethyl cyanophosphonate and diisopropylethylamine[1].
[1]. Sanderson RJ, et al. In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):843-52.
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