NIC3 |
| Catalog No.GC36735 |
NIC3는 선택적 측좌측핵 관련 단백질-1(NAC1) 억제제이며, NAC1의 보존된 Leu-90에 결합하여 동종이량체화를 방지하고 프로테아솜 NAC1 분해를 유도합니다. 항암 활성.
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Cas No.: 494830-67-0
Sample solution is provided at 25 µL, 10mM.
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NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor, binds to the conserved Leu-90 of NAC1, prevents its homodimerization, and leads to proteasomal NAC1 degradation. Anti-cancer activity[1]. NAC1[1]
[1]. Wang X, et al. Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents. J Biol Chem. 2019 May 17. pii: jbc.RA119.007664.
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