XY101 |
| Catalog No.GC37944 |
XY101은 IC50이 30nM이고 Kd가 380nM인 강력하고 선택적이고 대사적으로 안정하며 경구로 이용 가능한 RORγ 역작용제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2349368-16-5
Sample solution is provided at 25 µL, 10mM.
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XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM[1]. IC50: 30 nM (RORγ)[1]Kd: 380 nM (RORγ)[1]
XY101 potently inhibits cell growth, colony formation, and the expression of androgen receptor (AR), AR-V7 and prostate-specific antigen (PSA)[1].
XY101 exhibits significant antitumor activities during the treatment period with tumor growth inhibition and is well tolerated without obvious body weight loss[1].
[1]. Zhang Y, et al. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2019 May 9;62(9):4716-4730.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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