Metarrestin (Synonyms: ML246) |
| Catalog No.GC38201 |
메타레스틴(ML246)은 경구 활성, 동급 최초의 특정 핵주위 구획 억제제입니다. 메타레스틴은 적어도 부분적으로 번역 연장 인자 eEF1A2와 상호작용함으로써 핵 구조를 파괴하고 RNA 중합효소(Pol) I 전사를 억제합니다. Metarrestin은 전이 발달을 차단하고 마우스 암 모델에서 생존을 연장합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1443414-10-5
Sample solution is provided at 25 µL, 10mM.
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Metarrestin (ML246) disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis[1][2].
[1]. Vilimas T, et al. Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer. Cancer Chemother Pharmacol. 2018 Dec;82(6):1067-1080. [2]. Frankowski KJ, et al. Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis. Sci Transl Med. 2018 May 16;10(441).
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