Febrifugine (Synonyms: (+)-Febrifugine, NSC 315535) |
| Catalog No.GC38614 |
Febrifugine은 Dichroa febrifuga의 뿌리와 잎에서 발견되는 퀴나졸리논 알칼로이드로 항말라리아 활성이 있습니다.
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Cas No.: 24159-07-7
Sample solution is provided at 25 µL, 10mM.
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Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity [1].
[1]. Herman JD, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7(288):288ra77. [2]. McLaughlin NP, et al. The chemistry and biology of febrifugine and halofuginone. Bioorg Med Chem. 2014 Apr 1;22(7):1993-2004.
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