3-Hydroxyterphenyllin (Synonyms: NSC 299113) |
Catalog No.GC45337 |
3-Hydroxyterphenyllin은 Aspergillus candidus의 대사산물입니다. 3-Hydroxyterphenyllin은 증식을 억제하고 A2780/CP70 및 OVCAR-3 세포에 대한 세포독성을 유발합니다. 3-Hydroxyterphenyllin은 S기 정지 및 세포 사멸을 유도합니다. 3-Hydroxyterphenyllin은 난소암 연구의 잠재력이 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 66163-76-6
Sample solution is provided at 25 µL, 10mM.
3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methicillin-resistant S. aureus (MRSA) and V. vulnificus bacteria (MIC = 31 μg/ml for both).3 It also inhibits HIV-1 integrase in both coupled and strand transfer assays (IC50s = 2.8 and 12.1 μM, respectively).4
References
1. Kurobane, I., Vining, L.C., McInnes, A.G., et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by 1H and 13C nuclear magnetic resonance spectroscopy. J. Antibiot. (Tokyo) 32(6), 559-564 (1979).
2. Yen, G.-C., Chang, Y.-C., Sheu, F., et al. Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. J. Agric. Food Chem. 49(3), 1426-1431 (2001).
3. Wang, W., Liao, Y., Tang, C., et al. Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1. Mar. Drugs 15(11), E348 (2017).
4. Singh, S.B., Jayasuriya, H., Dewey, R., et al. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. J. Ind. Microbiol. Biotechnol. 30(12), 721-731 (2003).
Cas No. | 66163-76-6 | SDF | |
Synonyms | NSC 299113 | ||
Chemical Name | 3',6'-dimethoxy-[1,1':4',1''-terphenyl]-2',3,4,4''-tetrol | ||
Canonical SMILES | OC1=CC=C(C2=CC(OC)=C(C3=CC(O)=C(O)C=C3)C(O)=C2OC)C=C1 | ||
Formula | C20H18O6 | M.Wt | 354.4 |
Solubility | DMSO: soluble,Ethanol: soluble | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
1 mM | 2.8217 mL | 14.1084 mL | 28.2167 mL |
5 mM | 0.5643 mL | 2.8217 mL | 5.6433 mL |
10 mM | 0.2822 mL | 1.4108 mL | 2.8217 mL |
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Working concentration: mg/ml;
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Quality Control & SDS
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- Purity: >70.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5
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