SR 16832 |
| Catalog No.GC45566 |
SR 16832는 오르토스테릭 및 알로스테릭 부위에서 작용하는 이중 부위 공유 PPARγ 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2088135-12-8
Sample solution is provided at 25 µL, 10mM.
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SR 16832 is a dual-site covalent antagonist of peroxisome proliferator-activated receptor γ (PPARγ).1 It inhibits MRL20-induced allosteric activation of PPARγ in a reporter assay using HEK293T cells when used at a concentration of 5 μM. SR 16832 also reduces basal activity of PPARγ and inhibits binding of docosahexaenoic acid to PPARγ in a time-resolved FRET (TR-FRET) assay.
References
1. Brust, R., Lin, H., Fuhrmann, J., et al. Modification of the orthosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor. ACS Chem. Biol. 12(4), 969-978 (2017).
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