GNE-502 |
| Catalog No.GC65590 |
GNE-502는 에스트로겐 수용체(ER)에 대한 경구 활성 및 강력한 분해제입니다. GNE-502는 유방암 연구에 사용될 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1953134-16-1
Sample solution is provided at 25 µL, 10mM.
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GNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer[1].
GNE-502 (10 and 100 mg/kg; p.o.) possesses sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model[1].GNE-502 shows dose dependent tumor growth inhibition at 10 mg/kg and 30 mg/kg, with tumor stasis at 100 mg/kg[1].
[1]. Zbieg JR, et al. Discovery of GNE-502 as an Orally Bioavailable and Potent Degrader for Estrogen Receptor Positive Breast Cancer [published online ahead of print, 2021 Aug 20]. Bioorg Med Chem Lett. 2021;128335.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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