Helioxanthin 8-1 |
Catalog No.GC13722 |
헬리옥산틴 8-1은 헬리옥산틴의 유사체이며, >5/10/1.4/15 uM의 EC50으로 상당한 시험관내 항-HBV/HCV/HSV-1/HIV 활성을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 840529-13-7
Sample solution is provided at 25 µL, 10mM.
Helioxanthin 8-1, an analogue of helioxanthin (ACH126447), is an inhibitor of HBV and HIV virus with EC50 values of 0.03 μM and 2.7 μM, respectively [1].
Helioxanthin 8-1 is the cyclic hydrazide derivative of helioxanthin and has shown significant in vitro antivirus activity with EC50 values of 0.03 μM and 2.7 μM for HBV and HIV, respectively [1]. In the ds-tet5 cells, helioxanthin 8-1 can inhibit duck hepatitis B virus (DHBV) DNA synthesis with a mean IC50 value of 0.25±0.05 μM. Besides, in induced cells and non-induced ds-tet5 cells, helioxanthin 8-1 has cytotoxic effect with CC50 values of 18±2 μM and 45±3 μM, respectively, by using an MTT assay [2].
References:
[1] Yeo H1, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.
[2] Ying C1, Tan S, Cheng YC. Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21(2):97-103.
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