HQ461 |
| Catalog No.GC63854 |
HQ461은 CDK12-DDB1 상호작용을 촉진하여 사이클린 K 분해를 유발하는 분자 접착제입니다. 사이클린 K의 HQ461 매개 분해는 CDK12 기능을 손상시켜 CDK12 기질 인산화 감소, DNA 손상 반응 유전자의 하향 조절 및 세포 사멸을 초래합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1226443-41-9
Sample solution is provided at 25 µL, 10mM.
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HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death[1].
[1]. Lv L, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife. 2020 Aug 17;9:e59994.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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