JNJ-47965567 |
| Catalog No.GC43931 |
JNJ-47965567은 인간 및 쥐 P2X7에 대해 각각 7.9 및 8.7의 pKis를 갖는 중앙 투과성, 고친화성, 선택적 P2X7 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1428327-31-4
Sample solution is provided at 25 µL, 10mM.
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JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel. Activation of P2X receptors by BzATP induces calcium flux, which is reduced by JNJ-47965567 in 1321N1 cells transfected with recombinant P2X7 human, macaque, dog, rat, or mouse protein with pIC50s of 8.3, 8.6, 8.5, 7.2, or 7.5, respectively. JNJ-47965567 suppresses neonatal hypoxia-induced seizures in mice and has some anticonvulsant properties in rats. It also reduces spontaneous seizures in epileptic mice even after treatment is stopped.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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