OP-3633 |
| Catalog No.GC36809 |
OP-3633은 IC50이 29nM인 강력하고 선택적인 스테로이드 글루코코르티코이드 수용체(GR) 길항제이며 GR 전사 활성을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2102494-14-2
Sample solution is provided at 25 µL, 10mM.
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OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1]. IC50: 29 nM (GR)[1]
OP-3633 exhibits low progesterone receptor (PR) agonism with an EC50 higher than 2500 nM[1]. OP-3633 exhibits low androgen receptor (PR) antagonism, with an IC50 of 1135 nM[1].
[1]. Du X, et al. Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633). J Med Chem. 2019 Jul 25;62(14):6751-6764.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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