K-Ras ligand-Linker Conjugate 3 |
| Catalog No.GC39190 |
K-Ras 리간드-링커 접합체 3(화합물 001371)은 K-Ras 모집 부분에 대한 리간드와 E3 리가제(예: VHL, CRBN, MDM2 및 IAP)를 모집하는 PROTAC 링커를 통합합니다. K-Ras 리간드-링커 접합체 3은 SW1573 세포에서 ≥70% 분해 효능을 나타내는 강력한 PROTAC K-Ras 분해제인 PROTAC K-Ras 분해기-1의 합성에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2378261-87-9
Sample solution is provided at 25 µL, 10mM.
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K-Ras ligand-Linker Conjugate 3 (Compound 001371) incorporates a ligand for FAK (a KRas recruiting moiety), and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 3 can be extensively used for PROTAC-mediated protein degradation[1].
[1]. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2.
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